Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

Page 1 of about 5 results

ea0092op-04-01 | Oral Session 4: Young Investigators / Clinical and Translational | ETA2023

Interaction between DIO2 polymorphisms and LT4 treatment on psychological well-being outcomes and cardiovascular risk factors: a population-based cross-sectional study in uk biobank

Zinck Jensen Christian , Lynggaard Isaksen Jonas , Ahlberg Gustav , Salling Olesen Morten , Nygaard Birte , Ellervik Christina , Kim Kanters Jorgen

Objectives: Some evidence suggests gene-treatment interactions might cause persistent symptoms in individuals receiving levothyroxine (LT4) treatment. We investigated, as previously hypothesized, if single nucleotide polymorphisms (SNPs) in rs225014 (Thr92Ala), rs225015, or rs12885300 (ORFa-Gly3Asp) in the Deiodinase 2 gene (DIO2), or rs17606253 in the Monocarboxylate Transporter 10 gene (MCT10) were associated with outcomes indicative of local tissue hypothyroidism in LT4-tre...
0 shares

ea0084ps1-05-43 | Miscellaneous | ETA2022

Treatment of hyperthyroidism reduces the systemic oxidative stress load, as measured by biomarkers of rna and dna damage

Bogelund Larsen Camilla , Ryom Riis Kamilla , Hillert Winter Kristian , List Larsen Emil , Ellervik Christina , Hegedus Laszlo , Brix Thomas , Enghusen Poulsen3 Henrik , Joop Bonnema Steen

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abste...
0 shares

ea0070aep875 | Thyroid | ECE2020

Treatment of hyperthyroidism reduces the systemic oxidative stress load, as measured by biomarkers of RNA and DNA damages

Larsen Camilla , Ryom Riis Kamilla , Hillert Winter Kristian , List Larsen Emil , Ellervik Christina , Hegedüs Laszlo , Brix Thomas , Enghusen Poulsen Henrik , Joop Bonnema Steen

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abst...
0 shares

ea0070ep516 | Thyroid | ECE2020

Treatment of hypothyroidism does not affect whole-body oxidative stress, as measured by biomarkers of RNA and DNA damage

Ryom Riis Kamilla , Larsen Camilla , Winther Kristian H. , Larsen Emil L. , Ellervik Christina , Hegedüs Laszlo , Brix Thomas , Poulsen Henrik E. , Bonnema Steen J.

Background: Hyperthyroidism as well as hypothyroidism have been associated with oxidative stress, caused by an imbalance between pro-oxidants and antioxidants. Oxidative stress may damage the genomic apparatus and other cellular structures. Urinary excretion of 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent global RNA and DNA oxidation, thus reflecting oxidatively generated modification of nucleic acids in...
0 shares

ea0084ps2-06-53 | Hypothyroidism Treatment | ETA2022

Whole-body oxidative stress measured by biomarkers of RNA and DNA damage is higher in hypothyroid women, even after treatment, than in healthy individuals, measured by biomarkers of RNA and DNA damage

R. Riis Kamilla , B. Larsen Camilla , R. Medici Bjarke , Jensen Christian Z. , H. Winter Kristian , L. Larsen Emil , Bronden Andreas , Ellervik Christina , L. la Cour Jeppe , Hegedus Laszlo , H. Brix Thomas , E. Poulsen Henrik , Faber Jens , K. Knop Filip , Nygaard Birte , J. Bonnema Steen

Introduction: Hypothyroidism has been associated with oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent whole-body RNA and DNA oxidation. While these biomarkers have been associated with increased morbidity and mortality in various diseases, they have been only sparsely explored in patients with thyroid disorders.Method: In 45 women with newly diagn...
0 shares

Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 | Privacy policy | Cookie settings

BiosciAbstracts

Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.

Find out more